Nuclear Magnetic Resonance Spectroscopy of Amino-sugars. I. Conformation of Methyl 1 3, 6-Diamino-3, 6-dideoxy-α-D-altropyranoside and Its Derivatives
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The Conformations of 1-Thiacyclooctan-3-One Dynamic Nuclear Magnetic Resonance and Force-Field Calculation
The 1H and natural-abundance 13C-NMR spectra of 1-thiacyclooctan-3-one (1) have been measured from 25 to -100°C. Coalescence is observed in the 1H-NMR spectra of (1) at about -80°C, and attributed to ring inversion in a boat-chair conformation, which is the predominant conformation of (1). The free energy of activation (DG¹</s...
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In the title compound, C(10)H(12)N(2)S, one of the C atoms of the cyclo-hexene ring (at position 6) and the methyl group attached to it are disordered over two sets of sites in a 0.650 (3):0.350 (3) ratio. The cyclo-hexene ring in both the major and minor occupancy conformers adopts a half-chair conformation. The thio-phene ring is essentially planar (r.m.s. deviation = 0.05 Å). In the crystal,...
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Triphenyl phosphine(PPh3), an efficient and reusable catalyst, catalysed the synthesis of 2-amino-3-cyano-6-methyl-4-aryl-4H-pyran-5-ethylcarboxylate derivatives by one-pot condensation of aromatic aldehydes, malononitrile and ethyl acetoacetate in EtOH-H2O (1:1) at reflux conditions. The results show that ...
متن کاملthe conformations of 1-thiacyclooctan-3-one dynamic nuclear magnetic resonance and force-field calculation
the 1h and natural-abundance 13c-nmr spectra of 1-thiacyclooctan-3-one (1) have been measured from 25 to -100°c. coalescence is observed in the 1h-nmr spectra of (1) at about -80°c, and attributed to ring inversion in a boat-chair conformation, which is the predominant conformation of (1). the free energy of activation (dg¹) for this process is 9.2±0.2 kcal/mol. the 13c-nmr spectra of (1) is te...
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By the reaction of various amines with 3-chloropyridazines,several minaprine analogues were prepared.Most of them exhibited significant antidepressant activity.Compound 2a antagonizes reserpine action and neuroleptic-induced catalepsy in a dose-dependent manner. Keywords-disubstituted benzylidene pyridazine;3-amino pyridazine derivative,minaprine analogue;antidepressant activity Recently,it was...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1966
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.14.1112